Endothelin: Link between the Primary Placental Causes and the Secondary Systemic Endothelial Dysfunction in Pathophysiology of Pre-Eclampsia
نویسندگان
چکیده
Conclusion: In response to chronic reduction in uterine perfusion due to inadequate placentation, TNFα and IL-2 activates the endothelin system in placenta and vice-versa whereas IL-6 inhibits endothelium dependent NO-cyclic guanine monophosphate mediated relaxation pathway leading to development of systemic hypertension. This further compromises feto-placental circulation. It might be concluded, that ET-1 may be the key link between the primary placental causes and the secondary systemic endothelial dysfunction. ET-1 along with inflammatory cytokine levels may serve as a prognostic parameter, indicating the possibility of development of pre-eclampsia.
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